Targeted drug delivery had been proven an effective tool in the preparation of precision medicines which made it possible to treat deep tissue cancer like lung cancer without surgery. The purpose of this research was to synthesize a bio-compatible drug delivery system that can target affected areas of the tissue. Generally, theranostics include diagnostics and therapeutics modalities. The initial phase of this research was the fabrication of core-shell composite of Zn based shell with submicron mesoporous silica particles as core to load the drug; Zn based shell was used for diagnostics via photoluminescence spectroscopy (PLS). Zinc is an important constituent of the human body and hence, biocompatible for making it a promising bio-compatible drug delivery carrier. In the previous research, ZnO showed excellent optical properties respectively and had been proven to be promising for Biomedical imaging against cancer treatment. Using this approach, Submicron sized mesoporous hollow SiO₂ particles were prepared by sol-gel approach and ZnO nanoparticles by hydrothermal method and these were characterized by SEM, XRD, FTIR and PLS. The ZnO small particles (~20 nm) were coated on silica particle (~600 nm mesoporous capsules) via electrostatic forces owing to their opposite surface charges. Finally the confirmation of the composted formation was done by SEM and EDX. The as obtained composted was evaluated by MTT assay for their biomedical suitability.