Structural system plays a vital role in strength, functionality, aesthetics, and sustainable development of a building. Usually, reinforced cement concrete (RCC) structural system is mainly used for medium to high rise buildings. Although RCC is most economical and convenient structural system for low-rise buildings, however, this type of structural system is no longer economical for medium to high rise due to less stiffness, increased dead load, restriction on span and costly formwork. As an alternative to solely RCC and steel structural systems, their combined behavior has gained worldwide acceptance. In present work, RCC and hybrid structural system are considered for comparative analysis of high rise commercial building consisting of eleven floors situated in non-active seismic zone. A detailed analysis of both structural systems has been performed using the software “STAAD PRO”. Cost was calculated on basis of proposed geometrical design of both structural systems. It was observed that cost behaves differently for different structural members. Percentage increase and decrease in cost was observed for both type of structural systems and detailed comparison was made in this work that may be used for selection of such systems in a planning phase.