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ECO (Economic Cooperation Organization) as a regional organization emerged in 1985 and after the cold war the organization expanded with gradual progress. In this article achievements and failures of ECO objectives are explained by interdependence theory in the context of globalization. It is analyzed how the speed of globalization, growth of technology and interdependence have impacted on regionalism in ECO region particularly after the Cold War. Trade, energy and transportation are the key factors of ECO which are pushed by globalization and interdependence in regional and international levels. EU, India, East Asia and China have considerably suffering the shortage of energy and are dependent on ECO as a top richest energy in the world. On the other hand ECO is also facing low standard technology and is dependent on EU, China and other advanced countries. Interdependence not only has been happening in the world, but also within the region