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Though Tehrik-e-Taliban Pakistan (TTP) is significantly weakened and dislodged from former Federally Administered Tribal Areas (FATA) yet, it has relocated to bordering areas in Afghanistan under ideological umbrella of the Islamic State in Iraq and Syria (ISIS) and gets operational and logistics support through Afghan and Indian intelligence agencies. ISIS, having been greatly marginalized in the Middle East is struggling to gain foothold in Afghanistan with TTP as its proxy to execute the deadly terrorist attacks in Pakistan. The presence of ISIS in Afghanistan not only poses threat to Afghanistan but its collusion with TTP threatens Pakistan’s internal security as well. Pakistan’s sacrifices go in vain if cooperation from Afghanistan and the US forces is not forthcoming in defeating ISIS and TTP operating from Afghanistan. The article argues while domestic reforms and effective implementation of National Action Plan (NAP) by Pakistan is important to quell extremism and terrorism from urban centres, the cooperation from regional countries, harbouring TTP is vital for the elimination of scourge of terrorism from the region