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The aim of this research work was to develop a chemically cross-linked polymer-based hydrogel that is environmentally benign, economic, and pH sensitive. PVA mixed with Alginate and cross-linked with tetraethyl ortho silicate (TEOS). Alginate/PVA based hydrogel was synthesized for controlled drug delivery systems. The characterization of hydrogel was done by different techniques FTIR, SEM, TGA, and UV-VIS Spectroscopy. Surface morphology of hydrogel was checked by Scanning electron microscopy (SEM), thermal stability of hydrogel was checked by Thermo gravimetric Analysis (TGA). A linkage between polymers of hydrogel was detected by Fourier transform infrared spectroscopy (FT-IR). It was found that hydrogel is porous which plays a key role in swelling. The swelling of hydrogel is checked in diverse solutions such as aqueous, electrolytic and pH (buffer as well as non-buffer solution). The swelling of hydrogel is maximum at low pH and minimum at high pH. The hydrogel was loaded with two different drugs, Sitagliptin and Ciprofloxacin HCl. For In-vitro release study both the drugs were selected as modal drug and studied in simulated gastric fluid (SGF) and simulated intestinal fluid (SIF). In SIF Sitagliptin release 99% in 180 minutes. The Ciprofloxacin HCl shows 98.8% release in SIF for 5 hours. So, Ciprofloxacin HCl and Sitagliptin both the drugs were compatible with Alginate/PVA hydrogel which is determined from drug release study of drugs.