JOURNAL OF FACULTY OF ENGINEERING & TECHNOLOGY, Vol 27, No 1 (2023)

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Synthesis and Characterization of Biomedical Hydrogels by Using Chemically Modified Biopolymers for Drug Delivery Application

Syed Aminullah, Saima Saleem, Safia Zahid, Sumra Afzal

Abstract


 

The aim of this research work was to develop a chemically cross-linked polymer-based hydrogel that is environmentally benign, economic, and pH sensitive. PVA mixed with Alginate and cross-linked with tetraethyl ortho silicate (TEOS). Alginate/PVA based hydrogel was synthesized for controlled drug delivery systems. The characterization of hydrogel was done by different techniques FTIR, SEM, TGA, and UV-VIS Spectroscopy. Surface morphology of hydrogel was checked by Scanning electron microscopy (SEM), thermal stability of hydrogel was checked by Thermo gravimetric Analysis (TGA). A linkage between polymers of hydrogel was detected by Fourier transform infrared spectroscopy (FT-IR). It was found that hydrogel is porous which plays a key role in swelling. The swelling of hydrogel is checked in diverse solutions such as aqueous, electrolytic and pH (buffer as well as non-buffer solution). The swelling of hydrogel is maximum at low pH and minimum at high pH. The hydrogel was loaded with two different drugs, Sitagliptin and Ciprofloxacin HCl. For In-vitro release study both the drugs were selected as modal drug and studied in simulated gastric fluid (SGF) and simulated intestinal fluid (SIF). In SIF Sitagliptin release 99% in 180 minutes. The Ciprofloxacin HCl shows 98.8% release in SIF for 5 hours. So, Ciprofloxacin HCl and Sitagliptin both the drugs were compatible with Alginate/PVA hydrogel which is determined from drug release study of drugs.

 


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Faculty of Engineering and Technology

University of the Punjab

Lahore-54590-Pakistan