Ninety four (94) Sorghum vulgare L. (Cherry) varieties/lines have been explored for resistant genetic resources against Drechslera sorokiniana, the leaf spot disease pathogen. Screening against this destructive entity has been carried out for the first time in field conditions against natural inoculums spreading on varieties through infected crop leaves existing in the vicinity areas of suburbs of Sargodha and Research areas of the FRI institute. Four (4) and 25 Sorghum varieties were found resistant and moderately resistant while 19 varieties were found susceptible and 23 varieties were found highly susceptible in normal crop season. Rest of the 23 Sorghum varieties were found moderately susceptible. As the disease is seed soil and air borne in nature so crop rotation will help greatly to reduce the disease inoculums in the field. Seed treatment with recommended fungicides at recommended doses will be proved helpful to reduce the disease since there is no ammune varieties are available in present circumstances. If the seed crop is sprayed after the infection occurs twice fortnightly, it will control the disease effectively. This study restores the information about the availability of genetic resources maintained in the country.