MYCOPATH, Vol 19, No 2 (2021)

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Synthesis of 1-phenylazo-2-naphthol and evaluation of its fungicidal potential against Sclerotium rolfsii

Syeda Basma Raza, Arshad Javaid, Iqra Haider Khan, Ejaz Ahmed, Hamza Shehzad, Aneela Anwar

Abstract


            Many azo compounds are known for their antifungal property. In the present study, synthesis of 1-phenylazo-2-naphthol (C16H12N2O) was carried out as an azo coupled dye through coupling reaction of phenyl diazonium salt and β- naphthol in ice-cold chilled water. The azo coupling preferably occurs at ortho position of the same ring since the charge density get reinforced at this position. The 1-phenylazo-2-naphthol-naphthol was characterized through FTIR. The antifungal activity was tested against a highly problematic soil-borne plant pathogen Sclerotium rolfsii. The compound was dissolved in dimethyl sulfoxide (DMSO) and mixed with malt extract broth to prepare 6 mL of 100 mg mL-1 growth medium. Its concentrations in the range of 0.78 to 100 mg mL-1 were tested against the fungal pathogen. None of the concentration was found antifungal. In contrast, all the concentrations increased the fungal biomass to variable extents ranging from 0 to 29%. This study concludes that 1-phenylazo-2-naphthol does not possess antifungal property against S. rolfsii.


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