The secretion of cell wall-degrading enzymes (CWDEs) is a vital virulence factor determining the infectivity of phytopathogenic fungi. In this study, we investigated the potential of Rhizopus oryzae MT4489 to secrete polygalacturonase (PGase) and cellulase enzymes using agro-industrial residues for solid state fermentation (SSF). Enzymes produced by R. oryzae in different substrates were evaluated at six concentrations: 0.25, 0.50, 0.75, 1.0, 1.25 and 1.50 g L^-1. Optimization of various substrate parameters including temperature, pH, fermentation time, moisture content and inoculum concentration was also evaluated. This experiment consisted of thirteen treatments, twelve were inoculated with R. oryzae strain and the control (without application). The laboratory assay was laid out in a completely randomized design and replicated three times. The highest PGase enzyme production (442.03 µmole mg^-1) was recorded at 1.25 g L^-1 in wheat bran inoculated with R. oryzae, while corn cobs yielded the greatest cellulase (488.44 µmole mg^-1) output at same concentration. Optimal levels of enzyme production were obtained at temperature and pH range values of 40 to 50 °C and 5 to 6, respectively. Maximum enzyme yield was recorded at inoculum concentration of 1×10⁵ and 72 to 96 h incubation time. Wheat bran and corn cobs were the best substrates for producing PGase and cellulase enzymes, respectively. The ability R. oryzae to produce CWDEs in this study suggests that it may exhibit virulence factors required to initiate disease in crops. This knowledge will be helpful to breeders in developing inhibitors of the enzymes in plants to stem the ravages of R. oyzae rot disease.