Recently the advent of new functional materials has revolutionized the biomedicine filed. Especially, the mesoporous hollow capsules type structures have been of particular focus due to their unique therasontic character. Among these, porous hollow silica  capsules are much promosing because of their drug cargo carrying characteristics combined with ultrasound contrast properties. In present study silica capsules were synthesized by sol/gel approach. Cetrimonium bromide (CTAB) was used as surfactant during process which was eliminated during thermal treatment. The surfactant can control the size of mesoporous silica capsules. Scanning electron microscope (SEM), specific surface areas analysis, FTIR and X-ray diffraction were employed to characterize the morphology, structure and physiochemical property of Hollow mesoporous silica. Silica was coated with Polyvinylpyrrolidone (PVP) to improve dispersion. Finally, biocompatibility of silica was confirmed by MTT assay in which Hep2c cancer cells were utilized. Overall silica hybrid capsule had capabilities to use as vehicle for drug delivery system.