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The new international political order came with the demise of Soviet Union in 1991 and U.S. emerged as a sole hegemon either having alliances with other strong militarily and economically states or the states which are not in the alliances but are not a threat to U.S’s power. The incident of 9/11 had further paved the way for U.S. to project its supremacy and strength over weak states and maintained the status of super power. As a result of having that much of power, U.S. started interfering into other states in domestic as well as in foreign issues. The relations between the U.S. and Muslims are decreasing. After the incident of September 11 and the Iraq war and latter the Afghanistan war, the world population both in the U.S and in the Muslim world is keener to stop violence. whereas their relations reached at its lowest and Muslim states trying are to bridge the gap between the U.S and the Muslims. The ideological aspirations are gradually growing into a wider conflict, mainly exaggerated by the publication of materials deemed offensive by Muslims and deemed expression of free thought by the U.S. Under these conditions, it’s the need of the time to encourage mutual respect, understanding between social, cultural and religious values of each group which is important for bridging the gap between the U.S and Muslims. The clash of civilization and major reasons of differences between Muslims and U.S are briefly described in this paper.