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The purpose of this study is to analyze the impact of organizational stress, knowledge management, and organizational change on organizational effectiveness. A valid questionnaire was distributed to administrative staff and faculty members of different educational institutes. 100 questionnaires were distributed in public and private educational sectors. 75 complete questionnaires were received at response rate of 75%. A non probability random sampling technique was used to select the sample. Pearson’s moment correlation and linear regression was applied to study the relationship between organizational stress, knowledge management, organizational change and organizational effectiveness. Results show significant relationship of factors and positive impact on organizational effectiveness. This research also discusses practical implicatios and research limitations.