A field study was carried out to evaluate the efficacy of various herbicides for controlling grassy weeds in wheat crop during winter 2011-12 at Adaptive Research Farm, Sheikhupura, Pakistan. Four herbicides viz. pinoxaden/cloquintocet-mexyl (Axial 100 EC) @ 825 mL ha^-1, clodinafop (Topik 15 WG) @ 300 g ha^-1, fenoxaprop-p-ethyl (Puma Super 75 EW) @ 1250 mL ha^-1, Iodo + mesosulfuron (Atlantis 3.6% WG) @ 400 g ha^-1 were used. A weedy check was also maintained for comparison. All the herbicides decreased total weed population and their biomass as compared to weedy check. Axial 100 EC @ 825 mL ha^-1 was found to be the most effective in reducing weeds population as well as weed biomass with maximum mortality. Axial herbicide reduced total weed density and total weed dry weight over control by 88% and 87%, respectively. This herbicide increased grain yield of wheat by 42% and also increased tillers per unit area, spike length, number of grains per spike, 1000-grain weight over weedy check control. The economic analysis showed that Axial herbicide gave the highest net benefits of Rs. 78200 ha^-1. The application of Topik herbicide gave maximum marginal rate of return (1056%) followed by spray of Axial herbicide which resulted in 877% MRR.