The citrus greening disease, also called as Huanglongbing (HLB) disease, is the main reason for the decline of citrus trees in all citrus-growing countries. The bacterial species Candidatus Liberibacter is responsible for citrus greening disease and quickly spread through citrus psyllid, resulting in serious economic losses. Due to symptomatic variations, it is difficult to diagnose this disease among citrus cultivars. The disease spreads through grafting. With the help of genetic engineering, the genes are incorporated in citrus cultivars to manage the disease. The NPR1 genes showed the resistance against this disease. The expression of NPR1 in phloem increased the disease resistance in transgenic cultivars. It is essential to plan definite strategies to control citrus decline due to citrus greening disease in Pakistan.