Bioactive metabolites extracted from beneficial fungi are explored as safe alternatives as compared to chemicals pesticides, for the suppression of many plant diseases. In the current study, culture filtrates and the organic fractions of Aspergillus spp. isolated from disease-suppressive soils and composts were evaluated for their capacity to suppress Phytophthora erythroseptica Pethybr. radial growth and to limit severityof pink rotdisease caused by this pathogen. Culture filtrates were found the mostactive at 20% (v/v) concentration. Maximum inhibition (32%) of the fungal pathogen was noted due to Aspergillus niger CH12 cell-free filtrates. Two fractions viz. chloroform and ethyl acetate of the filtrates of A. niger CH12, A. terreus CH2, A. terreus MC8 and Aspergillus sp. CH8 tested at 5% (v/v), reduced P. erythroseptica growth up to 85% compared to the control. All the original filtrates and both the organic fractions significantly reduced the severity of pink rot when tested on pathogen inoculated potato tubers. The lesion diameter and penetration induced by pink rot were significantly reduced by 30–85% and 55–93%, respectively, following treatments with the filtrates tested. The two organic fractions of filtrates tested significantly lowered pink rot disease severity by 78–90% compared to the P. erythroseptica-inoculated. These findings revealed that the secondary metabolites from the Aspergillus spp.isolates tested are rich in bioactive compounds with great potential to reduce potato pink rot disease severity.