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The objective of study was to identify the prevalence and prescribing trends of anti-diabetic drugs in type 2 diabetes mellitus according to standard treatment guidelines in different hospitals of Lahore. In this retrospective observational study, data was collected from prescriptions of ambulatory diabetic patients by different physicians practicing in different public sector hospitals of Lahore, from February 2016 to April 2016. For this purpose 100 prescriptions were evaluated from various hospitals of Lahore, Pakistan. Type 2 Diabetes Mellitus is more prevalent in 40-50years age group. Mono oral therapy which includes Metformin is more prescribed by physician as compared to any other groups of drugs. According to our study, standard guidelines were followed for biguanides which is first line therapy type 2 diabetes mellitus.